Increased focus is placed on the importance of smudge cells in connection with certain types of diagnoses.
A number of articles explore this subject and according to the article Percentage of Smudge Cells on Routine Blood Smear Predicts Survival in Chronic Lymphocytic Leukemia the writers suggest that the number of smudge cells may have important biologic correlations rather than being only an artifact of slide preparation.
Smudge Cells or Basket Cell-A Diagnostic Pitfall reviews that the smudge cells on the film will not be included in manual differential, thereby resulting in an undercounting of the actual lymphocytes present. So education is needed.
This is an interesting discussion and we would … Read more »
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We would also like to thank you for your fantastic contribution to the blog over the past year and we hope to see you back here in the new year.
Using digital imaging to identify patients with atypical CLL (aCLL) is feasible, economical, and may provide clinically relevant prognostic information at diagnosis and during periodic monitoring according to a new study by Steven Marionneaux at Memorial Sloan Kettering Cancer Center, New York, NY.
Some insights from the study include:
27% of CLL cases were morphologically classified as atypical CLL. The aCLL group had a higher prevalence of trisomy 12, unmutated IgVH, and CD38 expression (markers associated with poor prognosis), and a lower prevalence of 13q14 deletion compared to typical CLL.
Traditional microscopic assessment … Read more »
We are glad to see that you are sharing your suggestions despite the limited information we could present for this case.
The patient was diagnosed with Burkitt’s Lymphoma, a cancer of the lymphatic system that has an especially high incidence in equatorial Africa among children 3 to 16 years of age. The disease is characterized by tumors of the jaw bones and abdomen and is named after Denis Burkitt, who mapped its peculiar geographic distribution across Africa in the 1950s.
There are three main clinical variants of Burkitt’s Lymphoma and they cannot really be distinguished from one another based on microscopic morphology. All types of Burkitt’s lymphoma are characterized … Read more »
Mystery cells case #17 presents a CSF sample of an unknown patient. The sample was analyzed using the CellaVision Body Fluid Application. Based on the image below, what diagnosis do you think was given?