FDA has cleared CellaVision Body Fluid Application for use with the cell morphology system for medium-sized laboratories, the CellaVision DM1200. By using the application, clinical laboratories are able to analyze spinal fluid, synovial fluid and pleural fluid among other body fluids.
Ron Hagner, Vice President Sales and Business Development at CellaVision North America, explains how the product works and improve upon already-available technology:
“To analyze body fluids quickly and effectively is an ideal solution for many laboratories, especially as the supply of qualified Medical Technologists is in rapid decline. The CellaVision DM1200 automatically scans a cytocentrifuge preparation of a body fluid, locates nucleated cell and using Artificial Neural Networks pre-classifies … Read more »
We gave out the result:
21.0% Segmented neutrophil
61.7% Lymphocyte (With comment: “activated”)
10.3% Other (with comment: “Atypical mononuclear cells with immature appearance (Virucytes?)) “
I called the department and asked if they suspected infectious mononucleosis. I have seen mononucleosis-cells before, but as I recall they look more like large, activated lymphocytes.
The answer was yes, and 2 days later, the diagnosis was confirmed by a positive Epstein -Barr test (EBV).
Normally we do not have this kind of “benign” disease at Rigshospitalet. Usually, we look for malignant haematological diseases.
In 1923, Downey divided the atypical lymphocytes into 3 types. But of … Read more »
This interesting mystery cells case is presented by Margit Grome, Biomedical Laboratory Scientist, Department of Clinical Biochemistry at Rigshospitalet, Copenhagen University Hospital.
Here are the patient details:
A 4 year-old boy, hospitalized at the Department of Paediatrics.
Cell count at the Sysmex XE-2100 showed, click to enlarge.
The Sysmex XE-2100 could not perform a differential count but gave the alarm:
“Atypical Lympho ? and Abn Lympho/L_Blasts?”
We validated 400 cells in the CellaVision DM96. We were a bit surprised to see 10% of – rather immature looking – mononuclear cells.
Click to enlarge the cells.
What diagnosis do you suspect? Discuss with your colleagues … Read more »