Diagnosis for Cells Case #19: B-ALL
Acute lymphoblastic leukemia (ALL) is a clonal expansion of the lymphoid blasts in bone marrow, blood or other tissues. ALL can be either T or B lineage and B-ALL is the proliferation of the blasts of the B lineage. The incidence of ALL is approximately 4 cases per 100,000 per year with 80-85% of these being precursor B-ALL, the others precursor T-ALL. ALL is generally seen in children and 75% of cases are usually in children under 6 years of age. The overall cure rate in children is 85% and 50% in adults.
In this case, flowcytometry showed the blast cell population positive for CD34, 19, TdT, HLA-DR and CD79a and negative for CD20, MPO and CD117. The blast cell population was negative in the Sudan Black staining. Subsequent cytogenetic analysis revealed no detectable abnormalities.
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