2012-09-20

Mystery cells, case #12

Can anyone tell us the diagnosis?

The cells in this case were collected from a blood film run on a CellaVision®DM96 at Northern Plains Laboratory Bismarck, North Dakota, US.

The patient details are as follows:
84 year old male
WBC 30.7 x 10^9/l
RBC 3.72 x 10^12/l
Hemoglobin 112 g/l
HCT 34.1%
MCV 92  fl
PLT 131 x 10^9/l

Please share your suggested diagnosis!

42 thoughts on “Mystery cells, case #12”

  1. Quite a difficult case to diagnose on a simple CellaVision capture without cell markers etc. The WBC is quite low for a PLL.
    I would favour a lymphoma (large cell) with a differential diagnosis of PLL. The 2 cells alongside the two neutrophils look
    monocytoid so couldn’t rule out a monocytoid abnormality either.

  2. linfocitos de cromatina intermedia,podria ser un linfoma o una leucemia prolinfocitica,para la tipificacion exacta debemos realizar otras pruebas como el inmunofenotipo(citometria de flujo)e identificacion de alteraciones geneticas

  3. I agree with Prolymphocytic leukemia based on N/C, large proeminent nucleole and the aspect of the chromatin and the CBC parameter at this stage.

  4. This is not easy. I favour a large cell lymphoma in leukaemic phase with prolymphocytic leukaemia to be considered. I don’t think the chromatin is sufficiently dispersed to favour acute leukaemia. The apparent granules in several cells might just be stain deposit as there are similar objects between the cells.

Comment on this blogpost

Your email address will not be published. Required fields are marked *

Subscribe

I confirm that I have read and accept Membership Terms & Conditions and CellaVision’s Privacy Policy

I give CellaVision permission to contact me about other things not directly related to my membership

Do you have an interesting story to share?