Diagnosis for Cells Case #19: B-ALL

Acute lymphoblastic leukemia (ALL) is a clonal expansion of the lymphoid blasts in bone marrow, blood or other tissues. ALL can be either T or B lineage and B-ALL is the proliferation of the blasts of the B lineage. The incidence of ALL is approximately 4 cases per 100,000 per year with 80-85% of these being precursor B-ALL, the others precursor T-ALL. ALL is generally seen in children and 75% of cases are usually in children under 6 years of age.  The overall cure rate in children is 85% and 50% in adults.

In this case, flowcytometry showed the blast cell population positive for CD34, 19, TdT, HLA-DR and CD79a and negative for CD20, MPO and CD117. The blast cell population was negative in the Sudan Black staining. Subsequent cytogenetic analysis revealed no detectable abnormalities.

About the CellaVision Blog

This blog is created by CellaVision for laboratory professionals with a particular interest in hematology and digital cell morphology. Our aim is to inform, educate and inspire in equal measures – by highlighting interesting articles, sharing interesting patient cases and cell images, and presenting inspiring success stories from our community of CellaVision-users from around the world.

2 thoughts on “Diagnosis for Cells Case #19: B-ALL”

  1. Blasts appear to be of the L1 type ALL. Sudan Black stains myeloblasts and not lymphoblasts confirming them of being of the lymphocytic lineage.

Comment on this blogpost

Your email address will not be published.


I confirm that I have read and accept Membership Terms & Conditions and CellaVision’s Privacy Policy

I give CellaVision permission to contact me about other things not directly related to my membership

Do you have an interesting story to share?